|
rs1800796
|
|
Appendicitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
With this study we investigated the contribution of IL-6 (-572G/C rs1800796) and IL-6R (1:G.154448302 T > C rs7529229) polymorphisms on pathogenesis, and severity of AA in pediatric patients with AA: These results will guide further genetic researches to be performed on the role of IL-6 and IL-6R in AA.
|
26714766 |
2015 |
|
rs1800796
|
|
Acute appendicitis NOS (disorder)
|
|
0.010 |
GeneticVariation
|
BEFREE |
With this study we investigated the contribution of IL-6 (-572G/C rs1800796) and IL-6R (1:G.154448302 T > C rs7529229) polymorphisms on pathogenesis, and severity of AA in pediatric patients with AA: These results will guide further genetic researches to be performed on the role of IL-6 and IL-6R in AA.
|
26714766 |
2015 |
|
rs1800795
|
|
Dementia, Vascular
|
|
0.010 |
GeneticVariation
|
BEFREE |
While rs1800795 (CC or GC) genotypes alone increased the odds of developing VaD </span>by 2.2-fold, the presence of CC genotype of rs1801131 nullified this effect.
|
22015309 |
2012 |
|
rs2069849
|
|
Selective immunoglobulin A deficiency
|
|
0.010 |
GeneticVariation
|
BEFREE |
We observed an increased frequency of the -174C allele in IgAD patients (p = 0.005, odds ratio [OR] = 1.51, 95% confidence interval [CI] = 1.12-2.04) and a protective effect of the rs2069849_C allele (p = 0.007, odds ratio = 0.29, 95% CI = 0.09-0.76).
|
18486766 |
2008 |
|
rs2066992
|
|
Endometrial Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We observed a significant increase in risk of endometrial cancer of rs1524107 (IL6) (T/C, OR = 1.61, 95% CI = 1.09-2.37, p = 1.55 × 10<sup>-2</sup> ), rs2066992 (IL 6) (OR = 3.09, 95% CI = 2.11-4.53, p = 3.13 × 10<sup>-9</sup> ).
|
30828987 |
2019 |
|
rs2066992
|
|
Malignant neoplasm of endometrium
|
|
0.010 |
GeneticVariation
|
BEFREE |
We observed a significant increase in risk of endometrial cancer of rs1524107 (IL6) (T/C, OR = 1.61, 95% CI = 1.09-2.37, p = 1.55 × 10<sup>-2</sup> ), rs2066992 (IL 6) (OR = 3.09, 95% CI = 2.11-4.53, p = 3.13 × 10<sup>-9</sup> ).
|
30828987 |
2019 |
|
rs1524107
|
|
Malignant neoplasm of endometrium
|
|
0.010 |
GeneticVariation
|
BEFREE |
We observed a significant increase in risk of endometrial cancer of rs1524107 (IL6) (T/C, OR = 1.61, 95% CI = 1.09-2.37, p = 1.55 × 10<sup>-2</sup> ), rs2066992 (IL 6) (OR = 3.09, 95% CI = 2.11-4.53, p = 3.13 × 10<sup>-9</sup> ).
|
30828987 |
2019 |
|
rs1524107
|
|
Endometrial Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We observed a significant increase in risk of endometrial cancer of rs1524107 (IL6) (T/C, OR = 1.61, 95% CI = 1.09-2.37, p = 1.55 × 10<sup>-2</sup> ), rs2066992 (IL 6) (OR = 3.09, 95% CI = 2.11-4.53, p = 3.13 × 10<sup>-9</sup> ).
|
30828987 |
2019 |
|
rs1800797
|
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
We observed a non-significant association between rs1800795 and overall cancer risk, while rs1800797 was found to have a false positive association with overall risk of cancer.
|
29842912 |
2018 |
|
rs1800797
|
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
We observed a non-significant association between rs1800795 and overall cancer risk, while rs1800797 was found to have a false positive association with overall risk of cancer.
|
29842912 |
2018 |
|
rs1800795
|
|
Malignant Neoplasms
|
|
0.040 |
GeneticVariation
|
BEFREE |
We observed a non-significant association between rs1800795 and overall cancer risk, while rs1800797 was found to have a false positive association with overall risk of cancer.
|
29842912 |
2018 |
|
rs1800795
|
|
Primary malignant neoplasm
|
|
0.040 |
GeneticVariation
|
BEFREE |
We observed a non-significant association between rs1800795 and overall cancer risk, while rs1800797 was found to have a false positive association with overall risk of cancer.
|
29842912 |
2018 |
|
rs1800795
|
|
Arteriosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated whether the functional G174C polymorphism (rs1800795) of interleukin-6 gene is associated with vital exhaustion, a measure of chronic stress, or with preclinical atherosclerosis.
|
24630186 |
2014 |
|
rs1800795
|
|
Atherosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated whether the functional G174C polymorphism (rs1800795) of interleukin-6 gene is associated with vital exhaustion, a measure of chronic stress, or with preclinical atherosclerosis.
|
24630186 |
2014 |
|
rs1800795
|
|
Classical Hodgkin's Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated whether selected germline SNPs in IL10 (rs1800890, rs1800896, rs1800871, rs1800872), TNFA (rs1800629), IL6 (rs1800795), ILRN (rs419598), INFG (rs2430561) and CCL17 (rs223828) were associated with circulating levels of related cytokines at diagnosis and progression-free survival (PFS) in CHL.
|
24008079 |
2013 |
|
rs1800795
|
|
Malignant neoplasm of prostate
|
|
0.070 |
GeneticVariation
|
BEFREE |
We investigated the role of two functional polymorphisms, IL-6-174G>C (rs1800795) and IL-6-572C>G (rs1800796), in the development of prostate cancer.
|
26535651 |
2015 |
|
rs1800795
|
|
Prostate carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
We investigated the role of two functional polymorphisms, IL-6-174G>C (rs1800795) and IL-6-572C>G (rs1800796), in the development of prostate cancer.
|
26535651 |
2015 |
|
rs1800797
|
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated the relationships between single nucleotide polymorphisms (SNPs) of the interleukin (IL)-6 gene 174 G>C (rs1800795), 572 G>C (rs1800796), and 597 G/A (rs1800797) and coronary artery disease (CAD) risk in a Chinese population.
|
25299085 |
2014 |
|
rs1800796
|
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated the relationships between single nucleotide polymorphisms (SNPs) of the interleukin (IL)-6 gene 174 G>C (rs1800795), 572 G>C (rs1800796), and 597 G/A (rs1800797) and coronary artery disease (CAD) risk in a Chinese population.
|
25299085 |
2014 |
|
rs1800795
|
|
Adenoma of large intestine
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated the inter-relationships of serum levels of the inflammatory proteins CRP and in IL-6, single nucleotide polymorphisms (SNPs) in the CRP (rs1205, rs1130864, rs1800947) and IL6 (rs1800795) genes, and lifestyle factors with colorectal adenoma in a sigmoidoscopy-based case-control study of 271 adenoma cases and 539 age-, sex-, and race/ethnicity-matched controls in Hawaii.
|
20333461 |
2010 |
|
rs2069837
|
|
Takayasu Arteritis
|
|
0.720 |
GeneticVariation
|
GWASCAT |
We identified genetic susceptibility loci for Takayasu arteritis with a genome-wide level of significance in IL6 (rs2069837) (odds ratio [OR] 2.07, P = 6.70 × 10(-9)), RPS9/LILRB3 (rs11666543) (OR 1.65, P = 2.34 × 10(-8)), and an intergenic locus on chromosome 21q22 (rs2836878) (OR 1.79, P = 3.62 × 10(-10)).
|
25604533 |
2015 |
|
rs2069837
|
|
Takayasu Arteritis
|
|
0.720 |
GeneticVariation
|
BEFREE |
We identified genetic susceptibility loci for Takayasu arteritis with a genome-wide level of significance in IL6 (rs2069837) (odds ratio [OR] 2.07, P = 6.70 × 10(-9)), RPS9/LILRB3 (rs11666543) (OR 1.65, P = 2.34 × 10(-8)), and an intergenic locus on chromosome 21q22 (rs2836878) (OR 1.79, P = 3.62 × 10(-10)).
|
25604533 |
2015 |
|
rs1800795
|
|
Ischemic stroke
|
|
0.060 |
GeneticVariation
|
BEFREE |
We have previously observed that genetic profiles determined by the combination of five functionally significant single nucleotide polymorphisms (SNPs) (rs1800795, rs5498, rs5361, rs1024611, and rs679620) of genes encoding prototypical inflammatory molecules are associated with history of ischemic stroke.
|
20622166 |
2010 |
|
rs1800795
|
|
Experimental Organism Basal Cell Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We have found that the presence of C allele in rs1800795 IL-6 gene polymorphism was associated with increased risk of BCC (aOR 1.86; 95% CI 1.22-2.84; p = 0.004).
|
31342143 |
2019 |
|
rs1800795
|
|
Carcinoma, Basal Cell
|
|
0.010 |
GeneticVariation
|
BEFREE |
We have found that the presence of C allele in rs1800795 IL-6 gene polymorphism was associated with increased risk of BCC (aOR 1.86; 95% CI 1.22-2.84; p = 0.004).
|
31342143 |
2019 |